Dynamic variation in forebrain estradiol levels during song learning
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چکیده
منابع مشابه
Dynamic variation in forebrain estradiol levels during song learning.
Estrogens shape brain circuits during development, and the capacity to synthesize estrogens locally has consequences for both sexual differentiation and the acute modulation of circuits during early learning. A recently optimized method to detect and quantify fluctuations in brain estrogens in vivo provides a direct means to explore how brain estrogen production contributes to both differentiat...
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The enzyme aromatase, which converts androgens into oestrogens, is expressed throughout the brain in zebra finches. Aromatase is enzymatically active in both cell bodies and synaptic terminals of neurones of the songbird brain, particularly within the forebrain motor and auditory networks. Aromatisation within synaptic terminals could thus provide localised and acute modulatory oestrogens withi...
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ers to understand an enzyme’s mode of action, enabling observation of transient intermediates, conformational changes, and the determination of rate constants. Such information can be difficult to obtain because Brownian motion prevents solution-phase molecules from staying still for the length of time required to make meaningful measurements, and immobilization can alter an enzyme’s biochemica...
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ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2014
ISSN: 1932-8451
DOI: 10.1002/dneu.22228